Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties
نویسندگان
چکیده
منابع مشابه
extraction and acetylation of purified trypsin from bovin pancreas and study of some its physico-chemical properties
آنزیم تریپسین در شرایط قلیایی ناپایدار می باشد .و فعالیت پروتئولیتیکی تریپسین منجربه خود هضمی آن در جایگاههای خاصی می گردد. بنابر این آنزیمی با ناپایداری بالا محسوب میگردد. در سالهای اخیر موفق شدند که با ایجاد تغیرات شیمیایی با اضافه کردن فلزات خاص ، کلسیم و یا عمل استیلاسیون منجر به افزایش پایداری آنزیم تریپسین گردند. مطالعات در حال حاضر نشان می دهد که تریپسین استیله شده فعالیت آنزیمی خود را ...
15 صفحه اولInfluence of Heparin Chemical Modifications on its Antiproliferative Properties
Pulmonary hypertension due to chronic hypoxia is associated with increased quantities of smooth muscle cells (SMCs) in pulmonary arteries, due to thickening of the medial muscle layer in the proximal arteries and extension of the smooth muscle investment into preripheral, normally nonmuscular vessels (1–4). A number of factors are known to cause SMCs migration, such as serum, platelet-derived g...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 1996
ISSN: 0959-6658,1460-2423
DOI: 10.1093/glycob/6.3.355